手性有机小分子催化剂因具有反应条件温和、环境友好、催化剂易于回收利用、符合绿色化学的要求等优点，成为近年来不对称催化领域发展起来的一个研究热点。其中，手性环胍类有机小分子催化剂可用于不对称的Michael加成反应、Mannich反应、脱羧反应、胺化反应及炔烃的手性连烯重排反应等等，并可实现良好收率和立体选择性，充分显示了手性环胍小分子催化剂在不对称反应中的巨大潜力。

产品性质稳定，易于储存；

反应条件温和，反应易于操作；

反应底物范围广，可催化多种反应类型；

催化剂无金属残留，可用于制药或香精香料生产；

高度优势的产品价格，齐全的包装规格，国内现货量充足。

产品名称

CAS

(2S,6S)-双苄基五元二环胍

(2S,6S)-2,6-Di-benzyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole

877773-30-3

(2S,6S)-双叔丁基五元二环胍

(2S,6S)-2,6-Di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole

877773-38-1

1. Biomimetic Enantioselective Decarboxylative Reactions catalysed by chiral bicyclic guanidine;

2. Bicyclic guanidine-catalyzed enantioselective Phospha-Michael reaction;

3. Bicyclic Guanidine-Catalyzed Direct Asymmetric Allylic Addition of N-Aryl Alkylidene-Succinimides;

4. Enantioselective Protonation Catalyzed by a Chiral Bicyclic Guanidine;

5. Chiral bicyclic guanidine catalysed Mannich reaction;

6. Enantiodivergent and g-Selective Asymmetric Allylic Amination;

7. Enantioselective Synthesis of Chiral Allenoates by Guanidine-Catalyzed Isomerization of 3-Alkynoates.

Ref.:

[1].Chem. Eur. J.2011, 17, 8363 - 8370;

[2].Chemical Commununications,2007, 47, 5058-5060;

[3].Chem. Eur. J.2010, 16, 12534 - 12537;

[4].Angew. Chem. Int. Ed.2008, 47, 5641 - 5645;

[5].a).Chem. Eur. J.2011, 17, 3571 - 3574;b).Chem. Eur. J.2010, 16, 779 -782;

[6].Angew. Chem. Int. Ed.2012, 51, 1 - 6;

[7].J. Am. Chem. Soc.2009, 131, 7212 - 7213.

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