文獻鏈接：https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202300829
文獻引用產品：
| 貨號 |
英文名稱 |
中文名稱 |
CAS |
| S27484 |
Whey protein concentrate (WPC) |
分離乳清蛋白 |
84082-51-9 |
作者單位：陜西師范大學化學化工學院 應用表面與膠體化學教育部重點實驗室
摘要：Foliar fertilization acts as a ubiquitous component of conventional crop production, which brings considerable economic and ecological costs. Due to droplets rebounding and splashing during spraying and rain erosion, low bioavailability of fertilizer results in severe environmental pollution. Contrary to conventional fertilizer formulations with polymers, surfactants, and organic reagents, a method of improving fertilizer bioavailability based on a biocompatible protein coating is presented herein. In this system, whey protein concentrate (WPC) can undergo amyloid-like aggregation after the reduction of its disulfide bond by the reducing agent tris(2-carboxyethyl) phosphine (TCEP). Such aggregation affords a fast formation of the optically transparent and colorless phase-transitioned WPC (PTW) coating at the solid/water interface, with robust interfacial adhesion stability. Upon packaging with fertilizers through electrostatic and hydrogen-bonding interactions, such reliable interfacial adhesion thereby facilitates the effective deposition of fertilizers on superhydrophobic and hydrophobic leaf surfaces, with excellent adhesion stability. Based on practical farmland test, this work demonstrates that the application of PTW can significantly boost the bioavailability of fertilizers and decrease at least 30% fertilizer use in large-scale crop planting. This innovative strategy has the great potential to offer a transformative step forward in managing fertilizer contamination and overuse in future agriculture.
文獻鏈接：https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202210679
文獻引用產品：
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貨號
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英文名稱
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中文名稱
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CAS
|
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S30381
|
Alloxan
|
四氧嘧啶 一水合物
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2244-11-3
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S10054
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Collagenase type II
|
膠原酶
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9001-12-1
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作者單位：南京鼓樓醫院風濕免疫科，東南大學生物科學與醫學工程學院
摘要：Oral administration is a most convenient way with good patient compliance for drug delivery; while it remains challenge to achieve desirable bioavailability of most macromolecules due to the complex gastrointestinal barriers. Here, inspired by the structure and function of rocket, we present a novel micro-motor delivery system with scaled-down rocket-like architecture and effervescent-tablets-derived fuel for efficient oral macromolecule delivery by penetrating intestinal barrier. These rocket-inspired effervescent motors (RIEMs) are composed of sharp needle tips for both loading cargoes and efficient penetrating, and tail wings for loading effervescent powders and avoiding perforation. When exposing to water environment, the effervescent-tablets-derived fuel of the RIEMs generates intensive CO2 bubbles to propel themselves to move at high speed. Thus, the RIEMs with sharp tip can inject into surrounding mucosa for effective drug releasing. Furthermore, due to their tail wings design, perforation can be effectively avoided during the injection process, ensuring the safety of RIEMs in gastrointestinal active delivery. Based on these advantages, we have demonstrated that the RIEMs can efficiently move and stab into the intestinal mucosa for insulin delivery, exhibiting efficacy in regulating blood sugar level of the diabetic rabbit model. These features indicate that our RIEMs are versatile and valuable for clinical oral macromolecules delivery.
| 貨號 |
英文名稱 |
中文名稱 |
CAS |
| S10205 |
aminopeptidase M |
亮氨酸氨基肽酶 |
9054-63-1 |
作者單位：清華大學醫學院生物醫學工程系，清華大學-北京大學生命科學聯合中心
摘要：The extracellular matrix of cirrhotic liver tissue is highly crosslinked. Here we show that advanced glycation end-products (AGEs) mediate crosslinking in liver extracellular matrix and that high levels of crosslinking are a hallmark of cirrhosis. We used liquid chromatography–tandem mass spectrometry to quantify the degree of crosslinking of the matrix of decellularized cirrhotic liver samples from patients and from two mouse models of liver fibrosis and show that the structure, biomechanics and degree of AGE-mediated crosslinking of the matrices can be recapitulated in collagen matrix crosslinked by AGEs in vitro. Analyses via cryo-electron microscopy and optical tweezers revealed that crosslinked collagen fibrils form thick bundles with reduced stress relaxation rates; moreover, they resist remodelling by macrophages, leading to reductions in their levels of adhesion-associated proteins, altering HDAC3 expression and the organization of their cytoskeleton, and promoting a type II immune response of macrophages. We also show that rosmarinic acid inhibited AGE-mediated crosslinking and alleviated the progression of fibrosis in mice. Our findings support the development of therapeutics targeting crosslinked extracellular matrix in scarred liver tissue.